Millennium and Seattle Genetics Present Clinical Data on ADCETRIS ...

CAMBRIDGE, Mass. & BOTHELL, Wash.--( EON: Enhanced Online News )--Millennium: The Takeda Oncology Company, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited (TSE:4502) and Seattle Genetics, Inc. (Nasdaq: SGEN), announced today that data on ADCETRIS™ (brentuximab vedotin) in relapsed or refractory Hodgkin lymphoma patients were featured in an oral presentation at the 16 Congress of the European Hematology Association (EHA) in London. The data from this retrospective analysis describe the activity and tolerability of ADCETRIS in Hodgkin lymphoma patients who were not candidates for or who refused autologous stem cell transplant (ASCT). ADCETRIS is an antibody-drug conjugate (ADC) directed to CD30, the defining marker of Hodgkin lymphoma.

“These data from our phase I trials support the activity and tolerability of ADCETRIS in patients for whom standard second-line induction therapy is not an option or has failed to produce a robust response prior to ASCT,” said Thomas C. Reynolds, M.D., Ph.D., Chief Medical Officer at Seattle Genetics. “We believe that patients in this setting represent a significant unmet medical need.”

“Further analysis of data from these phase I trials continues to add to the growing body of evidence of the potential of ADCETRIS to benefit a variety of Hodgkin lymphoma patients, including those who have not received a stem cell transplant,” said Nancy Simonian, M.D., Chief Medical Officer, Millennium.

Twenty relapsed or refractory Hodgkin lymphoma patients who were ineligible for or refused treatment with ASCT were among patients enrolled in two phase I dose-escalation trials of ADCETRIS conducted from 2006 to 2010. Six out of 20 patients (30 percent) achieved an objective response, including two (10 percent) complete remissions and four (20 percent) partial remissions. An additional 10 patients (50 percent) had stable disease. The median duration of response had not been reached at the time the trials closed. Two patients who attained complete remission maintained their remission after 10.7 and 13.8 months of follow-up, respectively.

ADCETRIS treatment was generally well tolerated, with the most common adverse events being fatigue (45 percent), nausea (40 percent), fever (35 percent), weight loss (30 percent) and diarrhea (30 percent).

Hermes Franca's jailhouse letter of love and faith | Fightlinker ...

The last we heard of Hermes Franca, he'd just been arrested for 'seven counts of Sexual Abuse in the first degree (ORS.163.427) as well as two counts of Unlawful Sexual Penetration in the second degree (ORS.163.408).' In layman's terms, "second degree unlawful sexual penetration in Oregon means penetration by something other than the mouth or penis of a girl under the age of 14." So basically, child diddling. I recently read a quote by David Goetz that stated, “Too much of the good life ends up being toxic, deforming us spiritually.” Wow!  This honestly hits home in my heart.  I am ashamed to admit that along the way I lost sight of what is truly important I life, God and unconditional love for my family and friends.  These are the things that should matter.

Goddamn, how someone rotting in prison with the worst accusation hovering over his head can be so positive is beyond me. I guess all things are possible through Christ and all that jazz, but if I were Hermes I'd be less than impressed with the plan God seems to have me. I'd be sending prayer daggers into celestial space every night hoping one of them gets Big J right in the junk. Then again, I know for a fact I haven't inserted 'something other than the mouth or penis' into a fourteen year old since I was fifteen.

This is a really fucked up situation.

I like Hermes a lot (at least up until the charges) and he seemed like a pretty good guy. Even when he tested positive for steroids he manned up and admitted it. He also flew back from Brazil to face the charges when I'm sure he could have disappeared just as easily. So, I'd like to believe that he is innocent but there must be some very serious statements and some kind of evidence to have him locked up until the trial.

However, should a 36 year old really be rolling with a 14 year old girl? I know he's the instructor, but all this mess (guilty or innocent) could have been avoided if he got another female student to be the minor's partner for any intimate contact/grappling. I'm all for men training with women, but when the woman is a 14 year old girl and the man is a 36 year old UFC fighter (former) it just seems like a terrible idea to be rolling with them. Any normal 36 year old man would realize the inappropriate nature involved in grappling with a minor of the opposite sex and would know better.

So did he sexually assault the minor? Not sure, and I'm hoping it's an unintentional misunderstanding by an oblivious instructor and an embarrassed student. But either way I'm sure that he must have crossed some kind of line to be up on seven charges of assault from a former student. Seven - wow.

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